Strongbridge Biopharma PLC (NASDAQ: SBBP) and Anika Therapeutics (NASDAQ:ANIK) are both small-cap medical companies, but which is the superior investment? We will contrast the two companies based on the strength of their valuation, profitability, earnings, risk, analyst recommendations, institutional ownership and dividends.


This table compares Strongbridge Biopharma PLC and Anika Therapeutics’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Strongbridge Biopharma PLC N/A -83.83% -34.77%
Anika Therapeutics 30.44% 14.88% 13.78%

Analyst Recommendations

This is a breakdown of current ratings and price targets for Strongbridge Biopharma PLC and Anika Therapeutics, as reported by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Strongbridge Biopharma PLC 0 0 3 0 3.00
Anika Therapeutics 0 0 0 0 N/A

Strongbridge Biopharma PLC currently has a consensus price target of $13.33, indicating a potential upside of 89.13%. Given Strongbridge Biopharma PLC’s higher possible upside, equities research analysts plainly believe Strongbridge Biopharma PLC is more favorable than Anika Therapeutics.

Earnings and Valuation

This table compares Strongbridge Biopharma PLC and Anika Therapeutics’ gross revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio EBITDA Earnings Per Share Price/Earnings Ratio
Strongbridge Biopharma PLC $1.53 million 162.82 -$39.43 million ($2.78) -2.54
Anika Therapeutics $111.36 million 6.81 $56.02 million $2.26 22.89

Anika Therapeutics has higher revenue and earnings than Strongbridge Biopharma PLC. Strongbridge Biopharma PLC is trading at a lower price-to-earnings ratio than Anika Therapeutics, indicating that it is currently the more affordable of the two stocks.

Institutional and Insider Ownership

81.3% of Anika Therapeutics shares are owned by institutional investors. 6.6% of Anika Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Risk and Volatility

Strongbridge Biopharma PLC has a beta of 2.62, meaning that its share price is 162% more volatile than the S&P 500. Comparatively, Anika Therapeutics has a beta of 1.69, meaning that its share price is 69% more volatile than the S&P 500.


Anika Therapeutics beats Strongbridge Biopharma PLC on 8 of the 12 factors compared between the two stocks.

About Strongbridge Biopharma PLC

Strongbridge Biopharma plc is a global commercial-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies for a range of diseases. The Company’s commercial product, KEVEYIS (dichlorphenamide), is indicated for the treatment of hyperkalemic, hypokalemic and related variants of primary periodic paralysis. The United States Food and Drug Administration (FDA) has granted orphan drug designation for KEVEYIS. The Company has a clinical-stage pipeline of therapies for endocrine diseases. The Company’s lead compounds include COR-003 (levoketoconazole), a cortisol synthesis inhibitor, and COR-005 (veldoreotide), a somatostatin analog (SSA). The Company is studying COR-003 for the treatment of endogenous Cushing’s syndrome. It is investigating COR-005 for the treatment of acromegaly. Both COR-003 and COR-005 have received orphan designation from the FDA and the European Medicines Agency (EMA).

About Anika Therapeutics

Anika Therapeutics, Inc. is an orthopedic medicines company. The Company is engaged in developing, manufacturing and commercializing products based on its hyaluronic acid (HA) technology. The Company’s orthopedic medicine portfolio includes ORTHOVISC, MONOVISC, and CINGAL, which alleviate pain and restore joint function by replenishing depleted HA, and HYALOFAST, a solid HA-based scaffold to aid cartilage repair and regeneration. The Company’s therapeutic offerings consist of products in the areas, including Orthobiologics, which includes viscosupplementation and regenerative orthopedic products; Dermal, which includes wound care products; Surgical, which includes products used to prevent post-surgical adhesions, and Other, which includes the Company’s ophthalmic and veterinary products. The Company also offers products made from HA based on two other technologies: HYAFF, which is a solid form of HA, and ACP gel, an autocross-linked polymer of HA.

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