Crispr Therapeutics (NASDAQ:CRSP) and LogicBio Therapeutics (NASDAQ:LOGC) are both medical companies, but which is the superior investment? We will compare the two companies based on the strength of their earnings, risk, valuation, dividends, profitability, analyst recommendations and institutional ownership.

Institutional & Insider Ownership

51.6% of Crispr Therapeutics shares are owned by institutional investors. Comparatively, 56.0% of LogicBio Therapeutics shares are owned by institutional investors. 21.4% of Crispr Therapeutics shares are owned by insiders. Comparatively, 49.9% of LogicBio Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

Analyst Recommendations

This is a breakdown of current ratings and price targets for Crispr Therapeutics and LogicBio Therapeutics, as provided by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Crispr Therapeutics 2 3 10 0 2.53
LogicBio Therapeutics 0 0 4 0 3.00

Crispr Therapeutics presently has a consensus price target of $58.30, indicating a potential upside of 23.33%. LogicBio Therapeutics has a consensus price target of $24.00, indicating a potential upside of 152.63%. Given LogicBio Therapeutics’ stronger consensus rating and higher possible upside, analysts plainly believe LogicBio Therapeutics is more favorable than Crispr Therapeutics.

Earnings & Valuation

This table compares Crispr Therapeutics and LogicBio Therapeutics’ revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Crispr Therapeutics $3.12 million 828.18 -$164.98 million ($3.44) -13.74
LogicBio Therapeutics N/A N/A -$17.62 million ($3.04) -3.13

LogicBio Therapeutics has lower revenue, but higher earnings than Crispr Therapeutics. Crispr Therapeutics is trading at a lower price-to-earnings ratio than LogicBio Therapeutics, indicating that it is currently the more affordable of the two stocks.


This table compares Crispr Therapeutics and LogicBio Therapeutics’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Crispr Therapeutics -15,136.56% -51.49% -40.08%
LogicBio Therapeutics N/A N/A N/A


LogicBio Therapeutics beats Crispr Therapeutics on 10 of the 12 factors compared between the two stocks.

About Crispr Therapeutics

CRISPR Therapeutics AG, a gene editing company, focuses on developing transformative gene-based medicines for the treatment of serious human diseases using its regularly interspaced short palindromic repeats associated protein-9 (CRISPR/Cas9) gene-editing platform in Switzerland. Its lead product candidate is CTX001, an ex vivo CRISPR gene-edited therapy for treating patients suffering from dependent beta thalassemia or severe sickle cell disease in which a patient's hematopoietic stem cells are engineered to produce high levels of fetal hemoglobin in red blood cells. The company is also developing CTX110, a donor-derived gene-edited allogeneic CAR-T therapy targeting cluster of differentiation 19 positive malignancies. In addition, it is developing allogeneic CAR-T programs targeting B-Cell maturation antigen and CD70; CTX120, a CAR-T cell product candidate for the treatment of multiple myeloma; CTX130 for the treatment of solid tumors and hematologic malignancies; programs to treat Hurler Syndrome and severe combined immunodeficiency disease, as well as glycogen storage disease Ia; and programs targeting diseases, such as Duchenne muscular dystrophy and cystic fibrosis. It has a collaboration agreements with Vertex Pharmaceuticals, Incorporated and Vertex Pharmaceuticals (Europe) Limited to develop, manufacture, commercialize, sell, and use various therapeutics; and StrideBio LLC to develop adeno-associated viral capsids. The company also has research collaboration agreements with Neon Therapeutics for developing neoantigen-based therapeutic vaccines and T cell therapies; Massachusetts General Hospital Cancer Center to develop T cell therapies for cancer; ViaCyte, Inc. for designing, developing, and commercializing gene-edited allogeneic stem cell therapies for the treatment of diabetes; and ProBioGen AG to develop novel in vivo delivery modalities for CRISPR/Cas9. CRISPR Therapeutics AG is headquartered in Zug, Switzerland.

About LogicBio Therapeutics

LogicBio Therapeutics, Inc., a genome editing company, focuses on developing medicines to treat rare diseases in patients with unmet medical need using GeneRide technology platform. The GeneRide technology is designed to integrate corrective genes into a patient's genome to provide a therapeutic effect. Its lead product candidate is LB-001 for the treatment of Methylmalonic Acidemia, a life-threatening disease that presents at birth. The company has a partnership with Children's Medical Research Institute to develop new viral vectors. LogicBio Therapeutics, Inc. was founded in 2014 and is headquartered in Cambridge, Massachusetts.

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