XOMA (NASDAQ: XOMA) and Osiris Therapeutics (OTCMKTS:OSIR) are both small-cap medical companies, but which is the better stock? We will compare the two companies based on the strength of their analyst recommendations, profitability, institutional ownership, risk, valuation, earnings and dividends.

Volatility and Risk

XOMA has a beta of 3.03, meaning that its share price is 203% more volatile than the S&P 500. Comparatively, Osiris Therapeutics has a beta of 0.87, meaning that its share price is 13% less volatile than the S&P 500.


This table compares XOMA and Osiris Therapeutics’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
XOMA -3.51% -1.14% 0.95%
Osiris Therapeutics N/A N/A N/A

Institutional & Insider Ownership

37.6% of XOMA shares are owned by institutional investors. Comparatively, 0.3% of Osiris Therapeutics shares are owned by institutional investors. 3.0% of XOMA shares are owned by company insiders. Comparatively, 44.6% of Osiris Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

Earnings & Valuation

This table compares XOMA and Osiris Therapeutics’ top-line revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
XOMA $5.56 million 42.37 -$53.53 million ($7.18) -4.03
Osiris Therapeutics N/A N/A N/A ($0.20) -43.45

Osiris Therapeutics has lower revenue, but higher earnings than XOMA. Osiris Therapeutics is trading at a lower price-to-earnings ratio than XOMA, indicating that it is currently the more affordable of the two stocks.

Analyst Recommendations

This is a summary of current ratings for XOMA and Osiris Therapeutics, as reported by MarketBeat.com.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
XOMA 0 0 2 0 3.00
Osiris Therapeutics 0 0 0 0 N/A

XOMA currently has a consensus target price of $41.00, suggesting a potential upside of 41.67%. Given XOMA’s higher probable upside, equities analysts plainly believe XOMA is more favorable than Osiris Therapeutics.


XOMA beats Osiris Therapeutics on 7 of the 11 factors compared between the two stocks.

About XOMA

XOMA Corporation is a development-stage biotechnology company. The Company focuses on the discovery and development of monoclonal antibody-based therapeutics. It has five products in its endocrine portfolio, two of which are developed as part of its XOMA Metabolism (XMet) platform. Its products include XOMA 358, XOMA 129, XOMA 213 and Gevokizumab. Its XOMA 358 is meant for long-acting treatment of hyperinsulinemic hypoglycemia. XOMA 129 is meant for rapid onset, short-acting treatment of severe acute hypoglycemia. XOMA 213 is a Phase II-ready product candidate targeting the prolactin receptor, as well as research-stage programs targeting the parathyroid receptor (PTH1R) and the adrenal corticotropic hormone (ACTH). Gevokizumab is a humanized monoclonal antibody with allosteric properties that has the potential to treat patients with a range of inflammatory diseases. Its technologies include Antibody Discovery Advanced Platform Technologies (ADAPT), ModulX and OptimX.

About Osiris Therapeutics

Osiris Therapeutics, Inc. is a cellular and regenerative medicine company. The Company is focused on researching, developing and marketing products in the wound, orthopedic, and sports medicine markets. The Company operates through Biosurgery business segment, which focuses on products for wound care, orthopedics, and sports medicine to harness the ability of cells and novel constructs to promote the body’s natural healing. The Company’s products include Grafix, Stravix, TruSkin, Cartiform and BIO4. The Company produces and distributes Grafix for acute and chronic wounds; Stravix for tendon repair; TruSkin for wound closure; Cartiform, a viable cartilage mesh for cartilage repair, and BIO4 for bone growth. The Company’s BioSmart cryopreservation process retains the native characteristics and inherent functionality of tissue. Its BioSmart process includes preservation of the three dimensional (3D) matrix, endogenous growth factors, and tissue-resident cells.

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