Head to Head Review: LifeStance Health Group (NASDAQ:LFST) versus Sema4 (NASDAQ:SMFR)

LifeStance Health Group (NASDAQ:LFST) and Sema4 (NASDAQ:SMFR) are both medical companies, but which is the better investment? We will contrast the two businesses based on the strength of their dividends, earnings, risk, institutional ownership, profitability, analyst recommendations and valuation.

Earnings and Valuation

This table compares LifeStance Health Group and Sema4’s top-line revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
LifeStance Health Group $265.56 million 11.72 -$13.13 million N/A N/A
Sema4 N/A N/A -$39.91 million N/A N/A

LifeStance Health Group has higher revenue and earnings than Sema4.

Insider and Institutional Ownership

71.7% of LifeStance Health Group shares are held by institutional investors. Comparatively, 74.1% of Sema4 shares are held by institutional investors. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Analyst Ratings

This is a summary of current ratings and price targets for LifeStance Health Group and Sema4, as provided by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
LifeStance Health Group 0 3 4 0 2.57
Sema4 0 0 4 0 3.00

LifeStance Health Group presently has a consensus target price of $23.50, suggesting a potential upside of 182.45%. Sema4 has a consensus target price of $12.50, suggesting a potential upside of 84.91%. Given LifeStance Health Group’s higher possible upside, analysts plainly believe LifeStance Health Group is more favorable than Sema4.


This table compares LifeStance Health Group and Sema4’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
LifeStance Health Group -37.13% -13.08% -9.42%
Sema4 N/A N/A N/A


Sema4 beats LifeStance Health Group on 5 of the 8 factors compared between the two stocks.

About LifeStance Health Group

LifeStance Health Group, Inc., through its subsidiaries, provides outpatient mental health services to children, adolescents, adults, and geriatrics. It offers patients a suite of mental health services, including psychiatric evaluations and treatment, psychological, and neuropsychological testing, as well as individual, family, and group therapy. It treats a range of mental health conditions, including anxiety, depression, bipolar disorder, eating disorders, psychotic disorders, and post-traumatic stress disorder. The company offers patients care virtually through its online delivery platform or in-person at its centers. LifeStance Health Group, Inc. was incorporated in 2021 and is based in Scottsdale, Arizona.

About Sema4

Sema4 Holdings Corp is a patient-centered health intelligence company. It is transforming healthcare by applying AI and machine learning to multidimensional, longitudinal clinical and genomic data to build dynamic models of human health and defining optimal, individualized health trajectories. Sema4 Holdings Corp, formerly known as CM Life Sciences, is based in STAMFORD, Conn.

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