G1 Therapeutics (NASDAQ: GTHX) and Geron (NASDAQ:GERN) are both small-cap medical companies, but which is the better business? We will contrast the two companies based on the strength of their profitability, earnings, institutional ownership, dividends, valuation, analyst recommendations and risk.

Analyst Recommendations

This is a breakdown of current ratings and recommmendations for G1 Therapeutics and Geron, as provided by MarketBeat.com.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
G1 Therapeutics 0 0 5 0 3.00
Geron 0 2 2 0 2.50

G1 Therapeutics presently has a consensus target price of $31.40, indicating a potential upside of 58.27%. Geron has a consensus target price of $4.17, indicating a potential upside of 131.48%. Given Geron’s higher probable upside, analysts plainly believe Geron is more favorable than G1 Therapeutics.

Profitability

This table compares G1 Therapeutics and Geron’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
G1 Therapeutics N/A N/A N/A
Geron -2,992.67% -25.14% -23.29%

Insider and Institutional Ownership

43.3% of G1 Therapeutics shares are held by institutional investors. Comparatively, 39.2% of Geron shares are held by institutional investors. 7.1% of Geron shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Earnings & Valuation

This table compares G1 Therapeutics and Geron’s revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
G1 Therapeutics N/A N/A N/A N/A N/A
Geron $6.16 million 46.53 -$29.53 million ($0.18) -10.00

G1 Therapeutics has higher earnings, but lower revenue than Geron.

Summary

G1 Therapeutics beats Geron on 6 of the 9 factors compared between the two stocks.

About G1 Therapeutics

G1 Therapeutics, Inc. is a United States-based clinical-stage biopharmaceutical company. The Company is engaged in developing small-molecule therapies for the treatment of cancer. Its two clinical-stage candidates are trilaciclib (G1T28) and G1T38, which are potent, selective inhibitors of the validated kinase targets CDK4/6. Trilaciclib and G1T38 are designed to be combined and enhance the anti-tumor activity of current therapies. It is also developing G1T48, an oral selective estrogen receptor degrader (SERD) for the treatment of breast cancer. The Company is evaluating trilaciclib in three Phase II clinical trials. G1T38 is being evaluated in combination with Faslodex in a Phase I b/II a trial for patients with estrogen receptor-positive, HER2-negative breast cancer.

About Geron

Geron Corporation (Geron) is a biopharmaceutical company, which supports the clinical stage development of a telomerase inhibitor, Imetelstat, in hematologic myeloid malignancies by Janssen Biotech, Inc. (Janssen). The Company is engaged in the development of therapeutic products for oncology. Using its nucleic acid chemistry, Geron designed Imetelstat to be an oligonucleotide that binds with high affinity to the ribonucleic acid (RNA) template of telomerase, thereby directly inhibiting telomerase activity. Janssen is engaged in the development of Imetelstat with two clinical trials, such as a Phase II trial in myelofibrosis (MF), referred to as IMbark, and a Phase II/III trial in myelodysplastic syndromes (MDS) referred to as IMerge. Imetelstat is a lipid conjugated 13-mer oligonucleotide that is designed to be complementary to and bind with high affinity to the RNA template of telomerase, thereby directly inhibiting telomerase activity.

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