Amicus Therapeutics (NASDAQ: EVLO) and Evelo Biosciences (NASDAQ:EVLO) are both medical companies, but which is the better investment? We will compare the two companies based on the strength of their profitability, valuation, earnings, dividends, institutional ownership, risk and analyst recommendations.

Analyst Recommendations

This is a summary of recent ratings and recommmendations for Amicus Therapeutics and Evelo Biosciences, as provided by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Amicus Therapeutics 0 2 5 0 2.71
Evelo Biosciences 0 0 4 0 3.00

Amicus Therapeutics currently has a consensus target price of $19.67, suggesting a potential upside of 46.11%. Evelo Biosciences has a consensus target price of $25.50, suggesting a potential upside of 92.60%. Given Evelo Biosciences’ stronger consensus rating and higher possible upside, analysts clearly believe Evelo Biosciences is more favorable than Amicus Therapeutics.


This table compares Amicus Therapeutics and Evelo Biosciences’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Amicus Therapeutics -460.04% -53.45% -32.85%
Evelo Biosciences N/A N/A N/A

Valuation and Earnings

This table compares Amicus Therapeutics and Evelo Biosciences’ gross revenue, earnings per share (EPS) and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Amicus Therapeutics $36.93 million 68.93 -$284.00 million ($2.92) -4.61
Evelo Biosciences N/A N/A -$28.04 million N/A N/A

Evelo Biosciences has lower revenue, but higher earnings than Amicus Therapeutics.

Insider & Institutional Ownership

80.5% of Evelo Biosciences shares are owned by institutional investors. 2.9% of Amicus Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.


Evelo Biosciences beats Amicus Therapeutics on 7 of the 10 factors compared between the two stocks.

Amicus Therapeutics Company Profile

Amicus Therapeutics, Inc., a biotechnology company, engages in the discovery, development, and commercialization of medicines for various rare and orphan diseases. The company offers migalastat HCl, an orally administered small molecule pharmacological chaperone for the treatment of Fabry disease. It is also conducting a Phase 1/2 clinical study of ATB200-02 to investigate in patients with pompe disease. The company has strategic alliance with GlaxoSmithKline plc to develop and commercialize migalastat as a monotherapy and in combination with ERT for Fabry disease. Amicus Therapeutics, Inc. was founded in 2002 and is headquartered in Cranbury, New Jersey.

Evelo Biosciences Company Profile

Evelo Biosciences, Inc., a biotechnology company, focuses on the development of monocolonal microbials for the treatment of inflammatory diseases and cancer. It is involved in developing EDP1066 and EDP1815 for patients with psoriasis and atopic dermatitis, rheumatoid arthritis, and ulcerative colitis/crohn's colitis; and EDP1503 for the treatment of colorectal cancer, renal cell carcinoma, and melanoma, as well as patients who have relapsed on prior PD-1/L1 inhibitor treatment across multiple tumor types. The company was founded in 2014 and is headquartered in Cambridge, Massachusetts.

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